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Title   간암 고위험군의 조기진단을 위한 선별검사 ( Screening ) 방안 수립 및 효과 평가 연구 ( Establishment of a Screenig Test System for Early Diagnosis of Hepatocellular Carcinoma in High - Risk Patients and the Evaluation of Its Effectiveness )
Publicationinfo   2000 Jan; 032(06): 1084-1093.
Key_word   Ultrasonograsphy , Screening , Hepatocellular carcinoma , Risk factors
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Abstract   Purpose: To evaluate the effectiveness of clinic-based screening program for early detection of hepatocellular carcinoma (HCC) and to assess the risk factors of HCC in Korea. Materials and Methods: The data of 14,259 patients who had ultrasonography (US) due to chronic liver diseases were collected into a data base program from 1990 to 1998. Results: A total of 4,339 patients were enrolled who had repeated US. 237 patients were diagnosed as HCC during follow-up (mean 33 months). The tumor size detected by screening within a 6-months interval was significantly smaller than that of a longer interval (2.7 cm vs 3.9 cm, P <0.01). The smaller the tumor was at detection, the longer the survival time was. Only 29.9% of HCC patients had an elevated serum alpha-fetoprotein ( a FP) level above 400 ng/ml. Multivariate analysis showed liver cirrhosis, chronic hepatitis B or C and old age over 40 years to be significantly associated with an increased risk of HCC. Conclusion: The US screening within a 6-months interval is beneficial to high-risk patients over 40 years old through the early detection of HCC and prolonged survival. According to the risk factors, the necessity for screening test and proper interval should be reconsidered.
저 자   한광협(Kwang Hyub Han),안상훈(Sang Hoon Ahn),김동기(Dong Ki Kim),송기준(Ki Joon Song),정정일(Jung Il Jeong),이관식(Kwan Sik Lee),정재복(Jae Bock Chung),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),서일(Il Suh),남정모(Jung Mo Nam)